The European Training Network (ETN) FOIE GRAS – Bioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease (NAFLD) – is an international doctoral school sponsored by H2020 Marie Sklodowska Curie Actions that will provide innovative training for 13 Early Stage Researchers (ESRs), in order to answer two critical questions:

a) Is hepatic bioenergetic remodelling involved in NAFLD pathogenesis, and target for stratification or therapeutic/lifestyle interventions?

b) Is the disruption of the gut-liver axis involved in NAFLD progression?

The overall aims of FOIE GRAS are:

1) to identify mechanisms and consequences of metabolic remodelling secondary to mitochondrial alterations during NAFLD;

2) to explore how the gut-liver axis is disrupted in NAFLD and how that impacts hepatic metabolism;

3) to identify related circulating biomarkers that will underpin better diagnostic tests for NAFLD and allow designing interventions that alleviate NAFLD through hepatic or gut metabolic remodelling.

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